Critical Effects


What is the underlying evidence or support for choices of critical effect(s)?

  1. What are the most robust sensitive or critical effects, adverse or that can progress to adverse, and considered relevant to humans?
  2. Are we using the  appropriate experimental animal species and outcomes?
  3. How should human epidemiology data be used, including evidence for associations with various health effects and the exposure levels at which these associations occur?
  4. What are the considerations for choice of uncertainty or safety factors applied to the point(s) of departure for the critical effect?