Based on current knowledge, what effects of PFAS in (or potentially in) humans are of greatest concern?
What information currently exists on the mechanisms or modes of action or AOPs of PFAS toxicity for PFAS and how do these mechanisms relate to compound structure? What is known about the toxicokinetics of PFAS, [...]
How should the human health risks of PFAS mixtures be assessed? Should all PFAS be considered as a single group? Could a TEF/RPF approach based on common mechanism or mode of action (or molecular initiating [...]
What is the optimal, feasible approach to characterize the toxicity of important PFAS (prioritized as necessary) to be used in a risk assessment context? What approaches (e.g., QSAR, read-across, microarray, in vitro key event assays) [...]
How could the health risks of PFAS in specific populations such as children, women and the aged be assessed? What role would non-animal methods, in vivo studies in experimental animals and epidemiological studies play?
How could current testing methods and predictive tools for evaluating the human health toxicity of PFAS be improved? What are the priorities for method development?
Could an integrated approach to human health and ecological toxicity assessment be productively applied to the PFAS issue?