PFAS Prioritization and Human Health

Based on current knowledge, what effects of PFAS in (or potentially in) humans are of greatest concern?

PFAS Prioritization and Human Health2019-08-15T12:41:51+00:00

Mechanisms of PFAS Toxicity

What information currently exists on the mechanisms or modes of action or AOPs of PFAS toxicity for PFAS and how do these mechanisms relate to compound structure? What is known about the toxicokinetics of PFAS, [...]

Mechanisms of PFAS Toxicity2019-08-15T12:44:59+00:00

Assessment Approaches

How should the human health risks of PFAS mixtures be assessed? Should all PFAS be considered as a single group? Could a TEF/RPF approach based on common mechanism or mode of action (or molecular initiating [...]

Assessment Approaches2019-08-15T12:46:59+00:00

Efficient Risk Assessment Frameworks for Human Toxicity

What is the optimal, feasible approach to characterize the toxicity of important PFAS (prioritized as necessary) to be used in a risk assessment context?  What approaches (e.g., QSAR, read-across, microarray, in vitro key event assays) [...]

Efficient Risk Assessment Frameworks for Human Toxicity2019-08-15T12:54:26+00:00

Human Biomonitoring

How could the health risks of PFAS in specific populations such as children, women and the aged be assessed? What role would non-animal methods, in vivo studies in experimental animals and epidemiological studies play?

Human Biomonitoring2019-08-15T12:56:28+00:00

Testing Models and Predictive Tools

How could current testing methods and predictive tools for evaluating the human health toxicity of PFAS be improved? What are the priorities for method development?

Testing Models and Predictive Tools2019-08-15T12:58:13+00:00
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