Should we be considering an integrated approach for the development of human health and ecological criteria?
What is the underlying evidence or support for choices of critical effect(s)? […]
What are the toxicokinetic extrapolations (considerations of species and gender differences; approaches for animal-human extrapolation and dose response modeling considerations) we should be using in the development of the toxicity basis for criteria?
What are the appropriate choices and exposure assumptions used in deriving criteria and undertaking risk assessments considering issues such as intake assumptions, multipathways, bioaccumulation and depuration?
What are some potential approaches for addressing PFAS as a group, or classes of PFAS as groups?
How do we validate exposure and uptake? How do we consider sensitivity and uncertainty in exposure and effects assessment and how they affect the differences in jurisdictional criteria?
How can we can include consideration of relationship between external exposure (e.g., concentration in drinking water or other media) and internal dose (e.g., blood serum level) of PFAS in risk characterization? Should we rely on [...]
Based on current knowledge, what effects of PFAS in (or potentially in) humans are of greatest concern?
What information currently exists on the mechanisms or modes of action or AOPs of PFAS toxicity for PFAS and how do these mechanisms relate to compound structure? What is known about the toxicokinetics of PFAS, [...]
How should the human health risks of PFAS mixtures be assessed? Should all PFAS be considered as a single group? Could a TEF/RPF approach based on common mechanism or mode of action (or molecular initiating [...]