Integrated Approaches

Should we be considering an integrated approach for the development of human health and ecological criteria?

Integrated Approaches2019-08-06T20:03:24+00:00

Critical Effects

What is the underlying evidence or support for choices of critical effect(s)? […]

Critical Effects2019-08-06T20:02:31+00:00

Toxicity Criteria

What are the toxicokinetic extrapolations (considerations of species and gender differences; approaches for animal-human extrapolation and dose response modeling considerations) we should be using in the development of the toxicity basis for criteria?

Toxicity Criteria2019-08-06T20:00:46+00:00

Exposure Assumptions

What are the appropriate choices and exposure assumptions used in deriving criteria and undertaking risk assessments considering issues such as intake assumptions, multipathways, bioaccumulation and depuration?

Exposure Assumptions2019-08-06T20:00:08+00:00

PFAS as a Group

What are some potential approaches for addressing PFAS as a group, or classes of PFAS as groups?

PFAS as a Group2019-08-06T19:58:53+00:00


How do we validate exposure and uptake? How do we consider sensitivity and uncertainty in exposure and effects assessment and how they affect the differences in jurisdictional criteria?


Measuring versus Modeling

How can we can include consideration of relationship between external exposure (e.g., concentration in drinking water or other media) and internal dose (e.g., blood serum level) of PFAS in risk characterization? Should we rely on [...]

Measuring versus Modeling2019-08-06T19:57:33+00:00

PFAS Prioritization and Human Health

Based on current knowledge, what effects of PFAS in (or potentially in) humans are of greatest concern?

PFAS Prioritization and Human Health2019-08-15T12:41:51+00:00

Mechanisms of PFAS Toxicity

What information currently exists on the mechanisms or modes of action or AOPs of PFAS toxicity for PFAS and how do these mechanisms relate to compound structure? What is known about the toxicokinetics of PFAS, [...]

Mechanisms of PFAS Toxicity2019-08-15T12:44:59+00:00

Assessment Approaches

How should the human health risks of PFAS mixtures be assessed? Should all PFAS be considered as a single group? Could a TEF/RPF approach based on common mechanism or mode of action (or molecular initiating [...]

Assessment Approaches2019-08-15T12:46:59+00:00
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